| NCAAF | 11/11 18:30 | 1 | Defiance Yellow Jackets v Bluffton Beavers | L | 35-42 | |
| NCAAF | 11/04 17:30 | 1 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 54-78 | |
| NCAAF | 10/28 17:30 | 1 | Manchester Spartans v Defiance Yellow Jackets | W | 27-51 | |
| NCAAF | 10/21 17:30 | 1 | Anderson Ravens v Defiance Yellow Jackets | W | 6-36 | |
| NCAAF | 10/14 17:30 | 1 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 21-35 | |
| NCAAF | 10/07 17:30 | 1 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 21-62 | |
| NCAAF | 09/30 17:30 | 1 | Hanover Panthers v Defiance Yellow Jackets | W | 21-27 | |
| NCAAF | 09/16 17:00 | 1 | Kalamazoo Hornets v Defiance Yellow Jackets | L | 42-35 | |
| NCAAF | 09/09 17:00 | 1 |
Adrian Bulldogs
v
Defiance Yellow Jackets
|
W | 17-34 | |
| NCAAF | 09/02 17:30 | 1 | Defiance Yellow Jackets v Mount Union | L | 6-45 | |
| NCAAF | 11/12 18:30 | 1 | Bluffton Beavers v Defiance Yellow Jackets | W | 14-17 | |
| NCAAF | 11/05 17:30 | 1 | Defiance Yellow Jackets v Manchester Spartans | W | 24-21 | |
| NCAAF | 10/29 17:30 | 1 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 76-35 | |
| NCAAF | 10/22 17:30 | 1 | Defiance Yellow Jackets v Anderson Ravens | W | 32-22 | |
| NCAAF | 10/15 17:30 | 1 | Franklin College Grizzlies v Defiance Yellow Jackets | L | 48-19 | |
| NCAAF | 10/08 17:30 | 1 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 55-35 | |
| NCAAF | 10/01 17:30 | 1 | Defiance Yellow Jackets v Hanover Panthers | L | 20-37 | |
| NCAAF | 09/24 16:00 | 1 |
Alfred State Pioneers
v
Defiance Yellow Jackets
|
L | 42-33 | |
| NCAAF | 09/17 17:30 | 1 | Defiance Yellow Jackets v Kalamazoo Hornets | L | 23-42 | |
| NCAAF | 09/03 17:30 | 1 | Mount Union v Defiance Yellow Jackets | L | 65-0 | |
| NCAAF | 11/13 18:30 | 1 | Defiance Yellow Jackets v Bluffton Beavers | L | 12-30 | |
| NCAAF | 11/06 17:30 | 1 | Anderson Ravens v Defiance Yellow Jackets | L | 42-14 | |
| NCAAF | 10/30 17:30 | 1 | Defiance Yellow Jackets v Franklin College Grizzlies | L | 7-13 | |
| NCAAF | 10/23 17:30 | 1 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 | |
| NCAAF | 10/16 17:30 | 1 | Hanover Panthers v Defiance Yellow Jackets | L | 51-0 | |
| NCAAF | 10/09 17:30 | 1 | Manchester Spartans v Defiance Yellow Jackets | L | 22-0 | |
| NCAAF | 10/02 17:30 | 1 | Defiance Yellow Jackets v Rose Hulman Engineers | L | 14-63 | |
| NCAAF | 09/25 16:00 | 1 |
Defiance Yellow Jackets
v
Alfred State Pioneers
|
L | 28-35 | |
| NCAAF | 09/11 17:30 | 1 | Defiance Yellow Jackets v Albion Britons | L | 0-51 | |
| NCAAF | 09/02 22:00 | 1 | Capital Crusaders v Defiance Yellow Jackets | L | 41-7 |